Clinical Trials from The University of Texas Health Science Center at Houston

Studies available for: Stroke

See a study that interests you? Contact that study's coordinator for more information on how to participate.

Study Information:

Study Title:RESPECT:The Randomised Evaluation of Stroke comparing PFO closure to Establised Current Standard of Care Treatment Trial.

Study Location:Houston, TX

Facility Name:Memorial Hermann Heart and Vascular Institue, TMC

Study Description:Patent foramen Ovale is one potential suspected cause of cryptogenic stroke. Cryptogenic stroke is a stroke that occurs without normal symptoms associated with stroke. It is not known what the best treatment is to reduce the risk of a recurrent stroke. AGA Medical Corporation is conducting the RESPECT Trial to investigate whether percutaneous closure of PFO using Amplatzer PFO occluder is superior to current standard medical management in preventing recurrent cryptogenic strokes or TIA. The study is a randomized, multi-center active control trial. Patients will be randomized to either receive the AMPLATZER PFO Occluder plus medical therapy or be treated with the current medical therapy standard of care.

HSC Number:HSC-MS-02-186

Funding Agency/Source:AGA Medical Corp.

Subject Information:

Subject Age Range:18-60 yrs.

Inclusion/Exclusion Criteria:Patients with PFO who have had a ‘cryptogenic stroke’ within the last 270 days, with stroke defined as follows: acute focal neurological deficit, presumed to be due to focal ischemia, and either 1) symptoms persisting 24 hours or greater, or 2) symptoms persisting less than 24 hours but associated with MR or CT findings of a new, neuroanatomically relevant, cerebral infarct. ‘Cryptogenic stroke’ is defined as a stroke from an unknown cause. “PFO” is defined as visualization of microbubbles per TEE in the left atrium within three cardiac

Study Coordinator(s) Information:

Name:Truc Baccam, RN

E-mail:Truc.Baccam@uth.tmc.edu

Phone Number:713-500-5214

Principal Investigator Information:

Name:Dr. Richard Smalling, Md, Ph.D.

Study Information:

Study Title:Improving Ambulation Post Stroke with Robotic Training

Study Location:Houston, TX

Facility Name:Memorial Hermann- TMC

Study Description:The purpose of this research study is to look at a new rehabilitation technique for people who have suffered a stroke causing difficulty walking. The present study is a research study designed to compare robotic-assisted rehabilitation therapy with standard physical therapy to improve walking after stroke.

HSC Number:HSC-MS-08-0206

Funding Agency/Source:Medallion Foundation

Subject Information:

Subject Age Range:18 and up

Inclusion/Exclusion Criteria:Inclusion Criteria: • Subjects with ischemic or hemorrhagic stroke confirmed by cerebral CT or MRI scan • Age>18 • At least 3 months post stroke at time of enrollment into study • Ability to walk at least 10 ft with maximum 1 person assist, but not to walk in the community independently • Residual paresis in the lower extremity as defined by the NIHSS lower extremity motor score 2-4 • Ability to perform Lokomat ambulation training with assistance of 1 therapist • Ability to follow a three-step command • Physician approval for patient participation • Ability to give informed consent • Completed their rehabilitation services, i.e., receiving no concurrent physical, occupational, or speech therapies Exclusion Criteria: • Serious ca

Study Coordinator(s) Information:

Name:Stephanie M. Hulsey

E-mail:Stephanie.Hulsey@memorialhermann.org

Phone Number:713-704-5636

Principal Investigator Information:

Name:Elizabeth A. Noser