Clinical Trials from The University of Texas Health Science Center at Houston

Studies available for: Congestive Heart Failure

See a study that interests you? Contact that study's coordinator for more information on how to participate.

Study Information:

Study Title:Relax HF Study: PhosphodiesteRase-5 inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure

Study Location:Houston, TX

Facility Name:Memorial Hermann Heart and Vascular Institute, TMC

Study Description:This is a double-blind, placebo controlled study testing the hypothesis that chronic PDE-5 inhibition (Sildenafil 20mg three times a day for 12 weeks followed by 60mg three times a day for 12 weeks) improves exercise capacity and clinical status in patients with heart failure and normal ejection fraction (Diastolic Heart Failure). Diastolic Heart Failure is a growing public health problem. Between 30-50% of patients with clinical Heart Failure have preserved ejection fraction. Mortality for Diastolic Heart Failure has been reported as similar to or slightly lower than that associated with Systolic Heart Failure. A recent study suggests that the prevalence of Diastolic Heart Failure is increasing and while survival among patients with Systolic Heart Failure has improved in recent years, survival for patients with Diastolic Heart Failure has not. The absence of proven therapy for Diastolic Heart Failure likely contributes to the lack of improvement in survival. Therefore, the scienti

HSC Number:HSC-MS-08-0531

Funding Agency/Source:National Heart, Lung and Blood Institute, National Institue of Health

Subject Information:

Subject Age Range:Age>18

Inclusion/Exclusion Criteria:clinical diagnosis of Heart Failure and normal ejection fraction (ЎЭ50%) with current NYHA class II-IV symptoms.

Study Coordinator(s) Information:

Name:Truc Baccam, RN

E-mail:Truc.Baccam@uth.tmc.edu

Phone Number:713-500-5214

Principal Investigator Information:

Name:Dr. Deborah Meyers,MD

Study Information:

Study Title:DOSE: Diuretic Optimization Strategies Evaluation in Acute Heart Failure

Study Location:Houston, TX

Facility Name:Memorial Hermann Heart and Vascular Institute, TMC

Study Description:This is a randomized, controlled, multi-center clinical trial of patients with signs and symptoms consistent with Acute Heart Failure (AHF) within 24 hours of hospital admission. This study will evaluate dosing strategies and route of administration for a commonly used, FDA approved medication for AHF (furosemide). There is little data to guide appropriate dosing of loop diuretics during AHF therapy, and consequently practice varies widely between physicians and centers. Similarly, substantial uncertainty remains about the optimal route of administration (continuous infusion vs. intermittent bolus) for IV diuretics. Patients will be randomized to one of 4 treatment regimens defined by a 2x2 factorial treatment design: • The balance between safety and efficacy of a “low intensification” vs. a “high intensification” dosing of loop diuretics in treating AHF. • The balance between safety and efficacy of continuous infusion vs. intermittent bolus administration of loop diuretics in

HSC Number:HSC-MS-09-0103

Funding Agency/Source:National Institutes of Health, National Heart, Lung and Blood Institute