Clinical Trials from The University of Texas Health Science Center at Houston

Studies available for: Substance Abuse

See a study that interests you? Contact that study's coordinator for more information on how to participate.

Study Information:

Study Title:Treatment of Cocaine Abuse/Dependence:

Study Location:Houston, TX

Facility Name:Mental Sciences Institute

Study Description:There is no single treatment for cocaine dependence that works for everyone, but certain medications may help in the treatment of cocaine abuse/dependence. Research in clinics like ours has found that the study drugs Modafinil and d-Amphetamine may have some benefit. This 16- week study will test Modafinil and d-Amphetamine to learn if they can reduce cocaine use. The study involves both medication and individual counseling sessions.

HSC Number:HSC-MS-06-0006

Funding Agency/Source:National Institute on Drug Abuse

Subject Information:

Subject Age Range:18-55

Inclusion/Exclusion Criteria:Inclusion Criteria- Subject must: • Be female or male (any race/ethnicity) ages 18-55. • Be in general good physical and psychiatric health except for possible acute drug-use related problems. • Be diagnosed by a health professional as meeting cocaine abuse/dependence per SCID criteria. • Subject may be HIV positive if in generally good health (unless medication interactions are problematic).

Study Coordinator(s) Information:

Name:Jan Lindsay, Ph.D.

E-mail:Jan.A.Lindsay@uth.tmc.edu

Phone Number:713-500-2800

Name:Thessalonica Jolley

E-mail:Thessalonica.Jolley@uth.tmc.edu

Phone Number:713-500-2800

Principal Investigator Information:

Name:Joy Schmitz, Ph.D.

CV:Information on the Principal Investigator

Study Information:

Study Title:Treatment of cocaine abuse/dependence during methadone maintenance for opiate dependence: Pharmacotherapy Dosing Regimen

Study Location:Houston, TX

Facility Name:Mental Sciences Institute

Study Description:Research clinics like ours have found that the study drugs Modafinil and Citalopram may have some benefit in treating drug abuse/dependence. This study will test Modafinil and Citalopram to learn if they can reduce cocaine use. This is a 24-week treatment trial involving both therapy and medication. There is no single treatment that works for everyone, but certain medicines may help in the treatment of cocaine abuse/dependence while you are regularly taking methadone. (Methadone is very effective in reducing opioid/heroin use).

HSC Number:HSC-MS-06-0240

Funding Agency/Source:National Institute on Drug Abuse

Subject Information:

Subject Age Range:22-50

Inclusion/Exclusion Criteria:Inclusion Criteria- Subject must: • Be female or male (any race/ethnicity) ages 22-50. • Be in general good physical and psychiatric health except for possible acute drug-use related problems. • Meet cocaine abuse/dependence and opiate dependence per SCID criteria. • Subject may be HIV positive if in generally good health (unless medication interactions are problematic).

Study Coordinator(s) Information:

Name:Jan Lindsay, Ph.D.

E-mail:Jan.A.Lindsay@uth.tmc.edu

Phone Number:713-500-2800

Name:Thessalonica Jolley

E-mail:Thessalonica.Jolley@uth.tmc.edu

Phone Number:713-500-2800

Principal Investigator Information:

Name:Joy Schmitz, Ph.D.

CV:Information on the Principal Investigator

Study Information:

Study Title:Screening Medications for Cocaine Cessation and Relapse Prevention

Study Location:Houston, TX

Facility Name:Mental Sciences Institute

Study Description:This is a 14-week study testing three medications (Levodopa/carbidopa, Naltrexone, and Modafinil) versus placebo (sugar pill) for the treatment of cocaine dependence. The study involves both individual counseling and medication.

More Information:website

HSC Number:HSC-MS-05-0331

Funding Agency/Source:National Institute on Drug Abuse

Subject Information:

Subject Age Range:18-55

Inclusion/Exclusion Criteria:Eligible participants will: 1. Be between 18 and 55 years of age. 2. Meet DSM-IV criteria for current cocaine dependence. 3. Be in acceptable health on the basis of interview, medical history and physical exam. 4. Be able to understand the consent form and provide written informed consent.

Study Coordinator(s) Information:

Name:Jan Lindsay, Ph.D.

E-mail:Jan.A.Lindsay@uth.tmc.edu

Phone Number:713-500-2800

Name:Thessalonica Jolley

E-mail:Thessalonica.Jolley@uth.tmc.edu

Phone Number:713-500-2800

Principal Investigator Information:

Name:Joy Schmitz, Ph.D.

Study Information:

Study Title:Impulsivity, Brain Function, and Substance Abuse Treatment

Study Location:Houston, TX

Facility Name:Mental Sciences Institute

Study Description:The purpose of this study is to find out how to better predict how a person will respond to treatment people take for cocaine dependence. This study will measure mood and memory and will collect a magnetic resonance image (MRI) of your brain. This information will be collected before treatment begins and after 8 weeks of treatment.

More Information:website

HSC Number:HSC-MS-05-0290

Funding Agency/Source:National Institute on Drug Abuse

Subject Information:

Subject Age Range:18-55

Study Coordinator(s) Information:

Name:Jan Lindsay, Ph.D.

E-mail:Jan.A.Lindsay@uth.tmc.edu

Phone Number:713-500-2800

Name:Thessalonica Jolley

E-mail:Thessalonica.Jolley@uth.tmc.edu

Phone Number:713-500-2800

Principal Investigator Information:

Name:F. G. Moeller, M.D.

Study Information:

Study Title:Behavior Therapy During Methadone Detoxification: A Comparison of Two Therapies

Study Location:Houston, TX

Facility Name:Mental Sciences Institute

Study Description:This is a 24-week study testing two types of individual therapy to see which is more effective in helping individuals to detoxify from methadone. All subjects will receive methadone that will be gradually reduced during the study. All subjects will receive one of the two therapies.

More Information:website

HSC Number:HSC-MS-04-397

Funding Agency/Source:National Institute on Drug Abuse

Subject Information:

Subject Age Range:25-55

Inclusion/Exclusion Criteria:Inclusion Criteria: to be included in the study, men and women of any race must be: (a) Between and including ages 25 through 55. (b) Dependent upon opiates (heroin/methadone) according to DSM-IV criteria. (c) Using heroin/methadone for at least 5 years. (d) In good physical and psychiatric health. (e) Able to read, speak, and understand English. (f) Willing and able to meet study requirements. (g) Willing to participate in the 1 month follow up session. (h) Attending a licensed methadone clinic regularly. (i) Want to detox from methadone.

Study Coordinator(s) Information:

Name:Jan Lindsay, Ph.D.

E-mail:Jan.A.Lindsay@uth.tmc.edu

Phone Number:713-500-2800

Name:Thessalonica Jolley

E-mail:Thessalonica.Jolley@uth.tmc.edu

Phone Number:713-500-2800

Principal Investigator Information:

Name:A. Stotts, Ph.D.